Genetic alterations of chromosome band 9p21 – 22 in head and neck cancer are not restricted to p16INK4a
نویسندگان
چکیده
منابع مشابه
Frequent loss of chromosome 9p21-22 early in head and neck cancer progression.
In order to define more clearly the role of chromosome 9 loss in head and neck squamous cell carcinoma (HNSCC), 29 invasive carcinomas and 17 preinvasive lesions were analyzed for loss of heterozygosity (LOH) on chromosome 9. We found LOH in 21 of 29 (72%) HNSCC tumors using highly polymorphic microsatellite markers. In 17 of 21, LOH was found at all informative sites on the p arm with no LOH o...
متن کاملVariable genetic alterations and survival in head and neck cancer.
OBJECTIVE To evaluate multiple genetic loci in patients with head and neck cancer to determine if, as in colorectal carcinoma, there is an orderly occurrence of genetic alterations, and if an accumulation of alterations affects patient survival. DESIGN Cohort study of patients with head and neck cancer in which fresh tissue was retrieved. SETTING Academic medical center. PATIENTS Forty-th...
متن کاملAlterations of p16-pRb pathway and chromosome locus 9p21-22 in sporadic invasive breast carcinomas.
The p16-pRb pathway represents a vital cell-cycle checkpoint. In the present study we investigated the alterations of this G1-phase protein pathway using immunohistochemical and molecular methods in a series of 55 breast carcinomas and correlated the findings with clinicopathological features of the patients. Furthermore, we examined its relationship with the status of the chromosomal region 9p...
متن کاملQuality of life in head and neck cancer patients
Quality of life in head and neck cancer patients
متن کاملQuality of Life in Head and Neck Cancer Patients with Xerostomia due to Radiotherapy
Background and Aim: Head and neck cancers (HNC) and their treatment can cause short-term and long-term impairment in patient’s quality of life (QOL). The aim of this study was to evaluate QOL in HNC patients suffering from xerostomia due to radiotherapy. Material and Methods: This Descriptive analytical study was performed on 44 HNC patients suffering from xerostomia experiencing radiotherapy f...
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ژورنال
عنوان ژورنال: Oncogene
سال: 1997
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1201336